Recombinant DNA Technology
In gel electrophoresis, DNA molecules migrate from __________ to __________ ends of the gel.

long ... short
negative ... positive
basic ... acidic
positive to negative

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Recombinant DNA Technology
Some genetic diseases cannot be diagnosed by changes in restriction sites. Some of these can be detected by allele-specific oligonucleotide probes. These are

PCR-amplified variable numbers of tandem repeats (VNTRs)
copies of the gene with an altered sequence so that a restriction site is inserted
mutagenized copies of a gene
short sequences that will hybridize only to a specific base sequence

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Recombinant DNA Technology
Isoschizomers recognize

same recognition site and recognition sequence
same recognition site and different recognition sequence
different recognition site and different recognition sequence
same recognition sequence but different recognition site

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