Water, pH and Macromolecules
Polyprotic acids such as H3PO4, can act as acid-base buffers

only in combination with polyprotic bases
at pH values around neutrality
at pH values around any of their pKa's
if their concentration is kept low

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Water, pH and Macromolecules
Hydrogen bonds and hydrophilic interactions are types of

strong chemical bonds that link together separate molecules
weak chemical bonds that hold together the atoms within a molecule
weak chemical bonds that link together separate molecules
strong chemical bonds that hold together the atoms within a molecule

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Water, pH and Macromolecules
Buffer solutions

are rarely found in living systems
cause a decrease in pH when acids are added to them.
tend to maintain a relatively constant pH.
will always have a pH of 7

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