Water, pH and Macromolecules
Polyprotic acids such as H3PO4, can act as acid-base buffers

only in combination with polyprotic bases
at pH values around neutrality
at pH values around any of their pKa's
if their concentration is kept low

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Water, pH and Macromolecules
Hydrogen bonds and hydrophilic interactions are types of

strong chemical bonds that hold together the atoms within a molecule
weak chemical bonds that link together separate molecules
weak chemical bonds that hold together the atoms within a molecule
strong chemical bonds that link together separate molecules

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