Protein Stability
Attractive Vander Waals forces occur between

apolar molecules in the liquid state
polar molecules in the solid state
only if other forces are less favorable
any pair of nearby atoms

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Protein Stability
Since ΔG° = -RTlnK

a 10-fold decrease in K decreases ΔG° by about 2.3*RT
a 10-fold increase in K decreases ΔG° by about 10-fold
a 10-fold increase in K decreases ΔG° by about 2.3*RT
a 10-fold decrease in K increases ΔG° by about 10-fold

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