Protein Stability
Attractive Vander Waals forces occur between

only if other forces are less favorable
polar molecules in the solid state
any pair of nearby atoms
apolar molecules in the liquid state

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Protein Stability
Since ΔG° = -RTlnK

a 10-fold decrease in K decreases ΔG° by about 2.3*RT
a 10-fold decrease in K increases ΔG° by about 10-fold
a 10-fold increase in K decreases ΔG° by about 10-fold
a 10-fold increase in K decreases ΔG° by about 2.3*RT

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