Protein Stability
Attractive Vander Waals forces occur between

apolar molecules in the liquid state
any pair of nearby atoms
polar molecules in the solid state
only if other forces are less favorable

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Protein Stability
Which of the following is the most correct?

All hydrophobic amino acids are buried when a protein folds
Tyrosine is only found in the interior of proteins
Charged amino acids are never buried in the interior of a protein
Charged amino acids are seldom buried in the interior of a protein

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Protein Stability
Since ΔG° = -RTlnK

a 10-fold increase in K decreases ΔG° by about 2.3*RT
a 10-fold decrease in K decreases ΔG° by about 2.3*RT
a 10-fold increase in K decreases ΔG° by about 10-fold
a 10-fold decrease in K increases ΔG° by about 10-fold

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