Allosteric Effects
An allosteric activator

both (a) and (c)
decreases the binding affinity
stabilizes the R state of the protein
increases the binding affinity

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Allosteric Effects
The conformational changes from the T to the R state is initiated by

movement of the proximal histidine towards the heme
movement of the F-helix, which contains the proximal His
reorganization of protein-protein contacts between the individual subunits
binding of oxygen to the heme

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