Allosteric Effects
A protein that binds two ligands in a non-cooperative manner will show

a sigmodial binding curve
both (b) and (c)
a hyperbolic binding curve
a linear Scatchard Plot

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Allosteric Effects
The conformational changes from the T to the R state is initiated by

binding of oxygen to the heme
reorganization of protein-protein contacts between the individual subunits
movement of the F-helix, which contains the proximal His
movement of the proximal histidine towards the heme

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