Allosteric Effects
The specificity of a ligand binding site on a protein is based on

the amino acid residues lining the binding site
the opposite chirality of the binding ligand
the presence of hydrating water molecules
the absence of competing ligands

ANSWER DOWNLOAD EXAMIANS APP

Allosteric Effects
The conformational changes from the T to the R state is initiated by

binding of oxygen to the heme
movement of the F-helix, which contains the proximal His
movement of the proximal histidine towards the heme
reorganization of protein-protein contacts between the individual subunits

ANSWER DOWNLOAD EXAMIANS APP