Allosteric Effects
In hemoglobin, allosteric effects occur

only in humans
for maintaining Fe in the Fe2+ state
to maximize oxygen delivery to the tissues
to minimize oxygen delivery to the tissues

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Allosteric Effects
O2 binding to hemoglobin results in

both (a) and (b)
100-fold lower affinity for the last O2 bound than for the first
extensive protein conformational change
100-fold higher affinity for the last O2 bound than for the first

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