Allosteric Effects
In hemoglobin, allosteric effects occur

to minimize oxygen delivery to the tissues
to maximize oxygen delivery to the tissues
for maintaining Fe in the Fe2+ state
only in humans

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Allosteric Effects
The conformational changes from the T to the R state is initiated by

movement of the F-helix, which contains the proximal His
reorganization of protein-protein contacts between the individual subunits
movement of the proximal histidine towards the heme
binding of oxygen to the heme

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