Allosteric Effects
O2 binding to hemoglobin results in

100-fold lower affinity for the last O2 bound than for the first
100-fold higher affinity for the last O2 bound than for the first
both (a) and (b)
extensive protein conformational change

ANSWER DOWNLOAD EXAMIANS APP

Allosteric Effects
The conformational changes from the T to the R state is initiated by

movement of the proximal histidine towards the heme
movement of the F-helix, which contains the proximal His
binding of oxygen to the heme
reorganization of protein-protein contacts between the individual subunits

ANSWER DOWNLOAD EXAMIANS APP