Allosteric Effects
Small molecules affect hemoglobin (Hb) by

increasing Hb affinity for O2
increasing [H+]
decreasing Hb affinity for O2
increasing [H+] and decreasing Hb affinity for O2

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Allosteric Effects
Bisphosphoglycerate (BPG) cannot bind to the oxygenated R state of hemoglobin because

its binding pocket becomes too small to accommodate BPG
BPG binds to the R state with the same affinity as the T state
it is displaced from the heme by movement of the proximal histidine
it is displaced from the heme by oxygen

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