Water, pH and Macromolecules
Weak acids generally have pKa

pKa values greater than 2
that cannot be used to buffer
been seldom found in living systems
values less than 1

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Water, pH and Macromolecules
Hydrogen bonds and hydrophilic interactions are types of

weak chemical bonds that hold together the atoms within a molecule
strong chemical bonds that hold together the atoms within a molecule
weak chemical bonds that link together separate molecules
strong chemical bonds that link together separate molecules

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