DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

It lacks a proofreading exonuclease
AZT (zidovudine) is too expensive to be taken in effective doses
The RNase H domain of p66 causes error prone synthesis
It has low affinity for the correct dNTP's

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