DNA Structure and Replication
DNA gyrase in E. coli

adds positive supercoils to chromosomal DNA
performs the same function as helicase in eukaryotes
is required only at the oriC site
can be inhibited with antibiotics

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DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

It lacks a proofreading exonuclease
It has low affinity for the correct dNTP's
The RNase H domain of p66 causes error prone synthesis
AZT (zidovudine) is too expensive to be taken in effective doses

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