DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

The RNase H domain of p66 causes error prone synthesis
AZT (zidovudine) is too expensive to be taken in effective doses
It has low affinity for the correct dNTP's
It lacks a proofreading exonuclease

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DNA Structure and Replication
Which of the following is used to determine the appropriate stringency (Wallace rule)?

Tm = 69.3° + 0.41 (%)G+C -650/1
Tm = 4 x (No.of G:C base pair) + 2 x (No.of A:T base pair)
Tm = 2 x (No.of G:C base pair) + 4 x (No.of A:T base pair)
Tm = 4 x (No.of A:T base pair) + 2 x (No.of G:C base pair)

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