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Antibiotics

Antibiotics
pH of the fermentation medium for chlorotetracyclins is

5-6
8-9
6-7
7-8

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Antibiotics
Which of the following event occurs during third phase of growth of P chrysogenum?

Slight rise in pH due to liberation of ammonia
Concentration of antibiotic increases in the medium
Autolysis of the medium starts
All of these

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Antibiotics
Which of the following event occurs during second phase of growth of P. chrysogenum?

pH increase
Mycelial mass increases
Both (a) and (b)
Synthesis of penicillin is high

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Antibiotics
Vegetable oil, (corn oil or soybean oil) added in the fermentation medium for penicillin, act as

carbon source
source of nutrients
both (a) and (c)
antifoam agent

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Antibiotics
Antibiotics are typically produced in fed batch reactors because

the precursors are often toxic to the cells
antibiotic yields are generally higher when cell growth slows
antibiotic yields are generally higher when cells enter the stationary phase
All of these

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Antibiotics
At acidic pH, penicillin remains in

solvent phase
aqueous phase
precipitates
both (a) and (b)

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