DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

It has low affinity for the correct dNTP's
AZT (zidovudine) is too expensive to be taken in effective doses
The RNase H domain of p66 causes error prone synthesis
It lacks a proofreading exonuclease

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