Gel Electrophoresis
In an SDS-PAGE

proteins are denatured by the SDS
proteins have the same charge-to-mass ratio
All of these
smaller proteins migrate more rapidly through the gel

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Gel Electrophoresis
Electrophoresis of histones and myoglobin under non-denaturing conditions (pH = 7.0) results in

histones migrate to the cathode and myoglobin migrates to the anode
both proteins migrate to the anode
both proteins migrate to the cathode
histones migrate to the anode and myoglobin migrates to the cathode

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