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Antimicrobial Chemotherapeutic Agents

Antimicrobial Chemotherapeutic Agents
Fluoroquinolones are antibiotics which inhibit

DNA polymerase
DNA gyrase
Cross-linking of peptidoglycan
RNA polymerase

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Antimicrobial Chemotherapeutic Agents
Who developed the concept of specific toxicity?

Fleming
Watson
Ehrlich
Pasteur

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Antimicrobial Chemotherapeutic Agents
Which of the following may cause resistance to penicillin?

All of these
Impermeability of cell envelope
Production of β-lactamases by bacteria
Alteration or lack of penicillin-binding proteins

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Antimicrobial Chemotherapeutic Agents
Polyene antibiotics are

large ring structures
β-lactam - thiazolidine ring
small ring structures
any of these

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Antimicrobial Chemotherapeutic Agents
The third generation cephalosporin agents is

cephalexin
cephalothin
cefoxitin
cefotaxime

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Antimicrobial Chemotherapeutic Agents
The mode of action of polymyxin is to

inhibit folic acid synthesis
injury to the plasma membrane
inhibit protein synthesis
inhibit DNA synthesis

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