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Antimicrobial Chemotherapeutic Agents

Antimicrobial Chemotherapeutic Agents
Fluoroquinolones are antibiotics which inhibit

DNA polymerase
RNA polymerase
Cross-linking of peptidoglycan
DNA gyrase

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Antimicrobial Chemotherapeutic Agents
Most antibiotics are isolated from

soil microorganisms
aquatic microorganisms
plants
viruses

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Antimicrobial Chemotherapeutic Agents
Both penicillin and fluoroquinolones

are inactivated by β-lactamase
inhibit the cross-linking of peptidoglycan
bind to and inactivate a bacterial protein
must be transported into the cytoplasm in order to act

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Antimicrobial Chemotherapeutic Agents
The antibiotics which affords a broad spectrum of antimicrobial coverage against aerobic and anaerobic bacteria, rickettsiae, chlamydiae, and mycoplasmas is

vancomycin
metronidazole
tetracycline
gentamicin

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Antimicrobial Chemotherapeutic Agents
The most selective antibiotics are those that interfere with the synthesis of

bacterial plasma membrane
bacterial cell walls
bacterial RNA
bacterial DNA

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Antimicrobial Chemotherapeutic Agents
Novobiocin can be used against

Haemophilus
gram +ve Staphylococci
all of these
gram -ve Meningococci & Gonococci

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MORE MCQ ON Antimicrobial Chemotherapeutic Agents

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