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Antimicrobial Chemotherapeutic Agents

Antimicrobial Chemotherapeutic Agents
Polyene antibiotics are

small ring structures
large ring structures
any of these
β-lactam - thiazolidine ring

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Antimicrobial Chemotherapeutic Agents
The antibiotics not having good activity against Enterobacteriaceae is

trimethoprim-sulphamethoxazole
cefoxitin
clindamycin
ciprofloxacin

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Antimicrobial Chemotherapeutic Agents
The antibiotics not clinically useful for Pseudomonas aeruginosa infection is

ceftazidime
aminoglycosides
trimethoprim-sulphamethoxazole
piperacillin

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Antimicrobial Chemotherapeutic Agents
Both penicillin and fluoroquinolones

inhibit the cross-linking of peptidoglycan
must be transported into the cytoplasm in order to act
are inactivated by β-lactamase
bind to and inactivate a bacterial protein

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Antimicrobial Chemotherapeutic Agents
The mode of action of polymyxin is to

inhibit protein synthesis
injury to the plasma membrane
inhibit DNA synthesis
inhibit folic acid synthesis

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Antimicrobial Chemotherapeutic Agents
The most selective antibiotics are those that interfere with the synthesis of

bacterial DNA
bacterial plasma membrane
bacterial cell walls
bacterial RNA

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