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ATP SYNTHESIS AND FATTY ACID OXIDATION

ATP Synthesis and Fatty Acid Oxidation
Membrane potential and the proton gradient

are sufficient, separately, to make ATP from ADP + Pi;
are both required to make ATP
cancel one another when uncouplers are present
reinforce one another when respiratory inhibitors are present

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ATP Synthesis and Fatty Acid Oxidation
The irreversibility of the thiokinase reactions (formation of initial acyl-CoA)

applies only to even-chain fatty acids
make this activation reaction the committed step on the pathway
both (a) and (b)
is due to the subsequent hydrolysis of the product

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ATP Synthesis and Fatty Acid Oxidation
Long-chain fatty acids are oxidized step-wise in one carbon units starting from the

none of these
aliphatic end
both (a) and (b)
carboxyl end

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ATP Synthesis and Fatty Acid Oxidation
How many molecules of acetyl-CoA are produced in oxidation of palmitic acid (C16), which involves seven rounds of oxidation?

9
6
7
8

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ATP Synthesis and Fatty Acid Oxidation
The oxidation of methanol (wood alcohol) in human retina tissue leads directly to the formation of

formaldehyde
CO2
none of these
sugars

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