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ATP SYNTHESIS AND FATTY ACID OXIDATION

ATP Synthesis and Fatty Acid Oxidation
Membrane potential and the proton gradient

cancel one another when uncouplers are present
are both required to make ATP
are sufficient, separately, to make ATP from ADP + Pi;
reinforce one another when respiratory inhibitors are present

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ATP Synthesis and Fatty Acid Oxidation
The irreversibility of the thiokinase reactions (formation of initial acyl-CoA)

applies only to even-chain fatty acids
make this activation reaction the committed step on the pathway
is due to the subsequent hydrolysis of the product
both (a) and (b)

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ATP Synthesis and Fatty Acid Oxidation
Long-chain fatty acids are oxidized step-wise in one carbon units starting from the

carboxyl end
both (a) and (b)
none of these
aliphatic end

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ATP Synthesis and Fatty Acid Oxidation
How many molecules of acetyl-CoA are produced in oxidation of palmitic acid (C16), which involves seven rounds of oxidation?

9
6
8
7

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ATP Synthesis and Fatty Acid Oxidation
The oxidation of methanol (wood alcohol) in human retina tissue leads directly to the formation of

formaldehyde
none of these
CO2
sugars

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