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ATP Synthesis and Fatty Acid Oxidation

ATP Synthesis and Fatty Acid Oxidation
How many molecules of acetyl-CoA are produced in oxidation of palmitic acid (C16), which involves seven rounds of oxidation?

8
6
7
9

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ATP Synthesis and Fatty Acid Oxidation
Long-chain fatty acids are oxidized step-wise in one carbon units starting from the

aliphatic end
none of these
both (a) and (b)
carboxyl end

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ATP Synthesis and Fatty Acid Oxidation
The irreversibility of the thiokinase reactions (formation of initial acyl-CoA)

both (a) and (b)
is due to the subsequent hydrolysis of the product
make this activation reaction the committed step on the pathway
applies only to even-chain fatty acids

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ATP Synthesis and Fatty Acid Oxidation
The transport of acyl-CoA for oxidation using a shuttle involves formation of the intermediate

acyl-carnitine
3 acetyl-CoA
Acyl-coenzyme A
None of these

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ATP Synthesis and Fatty Acid Oxidation
Membrane potential and the proton gradient

cancel one another when uncouplers are present
are sufficient, separately, to make ATP from ADP + Pi;
reinforce one another when respiratory inhibitors are present
are both required to make ATP

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ATP Synthesis and Fatty Acid Oxidation
Where the acyl-CoA formed in the cytosol is transported for oxidation?

Microsomes
Remains in cytosol
Endoplasmic reticulum
Mitochondrial matrix

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