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ATP Synthesis and Fatty Acid Oxidation

ATP Synthesis and Fatty Acid Oxidation
Long-chain fatty acids are oxidized step-wise in one carbon units starting from the

none of these
both (a) and (b)
carboxyl end
aliphatic end

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ATP Synthesis and Fatty Acid Oxidation
Where the acyl-CoA formed in the cytosol is transported for oxidation?

Endoplasmic reticulum
Mitochondrial matrix
Microsomes
Remains in cytosol

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ATP Synthesis and Fatty Acid Oxidation
Membrane potential and the proton gradient

cancel one another when uncouplers are present
are both required to make ATP
are sufficient, separately, to make ATP from ADP + Pi;
reinforce one another when respiratory inhibitors are present

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ATP Synthesis and Fatty Acid Oxidation
Each cycle of β-oxidation produces

1 FADH2, 1 NAD+, and 1 acetyl-CoA
1 FADH2, 1 NADH and 2 CO2 molecules
1 FAD, 1 NAD+ and 2 CO2 molecules
1 FADH2, 1 NADH and 1 acetyl-CoA

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ATP Synthesis and Fatty Acid Oxidation
The irreversibility of the thiokinase reactions (formation of initial acyl-CoA)

make this activation reaction the committed step on the pathway
both (a) and (b)
is due to the subsequent hydrolysis of the product
applies only to even-chain fatty acids

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ATP Synthesis and Fatty Acid Oxidation
How many molecules of acetyl-CoA are produced in oxidation of palmitic acid (C16), which involves seven rounds of oxidation?

6
8
9
7

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