Antigen
Antigen, when injected in the body activates its specific lymphocytes in the

spleen lymphoid tissue
MALT (mucosa associated
draining lymph nodes
blood circulation

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Antigen
For specific antigen recognition by T cells,

antigen is bound by a T cell membrane antibody
antigen exposure during T cell maturation is required
denaturation of antigen does not reduce epitope recognition
MHC molecules are not required

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
antigen is hidden from the immune system in macrophages
innate immunity blocks the activation of adaptive immune effector cells
innate immune effectors are eliminating antigen

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