Antigen
Antigen, when injected in the body activates its specific lymphocytes in the

blood circulation
spleen lymphoid tissue
draining lymph nodes
MALT (mucosa associated

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immune effectors are eliminating antigen
antigen is hidden from the immune system in macrophages
innate immunity blocks the activation of adaptive immune effector cells
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow

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