Antigen
A virus vaccine that can activate cytotoxic T cells must contain

live virus
a high dose of virus particles
virus peptides
an adjuvant to stimulate T cell division

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immunity blocks the activation of adaptive immune effector cells
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
antigen is hidden from the immune system in macrophages
innate immune effectors are eliminating antigen

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