Antigen
A virus vaccine that can activate cytotoxic T cells must contain

a high dose of virus particles
an adjuvant to stimulate T cell division
live virus
virus peptides

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immune effectors are eliminating antigen
antigen is hidden from the immune system in macrophages
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immunity blocks the activation of adaptive immune effector cells

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