Antigen
The ability of an antigen to induce an immune response does not depend on the antigen's

degree of aggregation
ability to enter the thyroid
size
dose

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Antigen
For specific antigen recognition by T cells,

antigen is bound by a T cell membrane antibody
antigen exposure during T cell maturation is required
MHC molecules are not required
denaturation of antigen does not reduce epitope recognition

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