Antigen
The ability of an antigen to induce an immune response does not depend on the antigen's

degree of aggregation
size
ability to enter the thyroid
dose

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immunity blocks the activation of adaptive immune effector cells
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immune effectors are eliminating antigen
antigen is hidden from the immune system in macrophages

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Antigen
For specific antigen recognition by T cells,

antigen exposure during T cell maturation is required
denaturation of antigen does not reduce epitope recognition
MHC molecules are not required
antigen is bound by a T cell membrane antibody

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