Antigen
The ability of an antigen to induce an immune response does not depend on the antigen's

size
degree of aggregation
dose
ability to enter the thyroid

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immune effectors are eliminating antigen
antigen is hidden from the immune system in macrophages
innate immunity blocks the activation of adaptive immune effector cells
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow

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