Antigen
Very low doses of antigen may induce

low zone immunity
hypersensitivity
immunological ignorance
low zone tolerance

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Antigen
For specific antigen recognition by T cells,

denaturation of antigen does not reduce epitope recognition
antigen exposure during T cell maturation is required
antigen is bound by a T cell membrane antibody
MHC molecules are not required

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Antigen
CD antigens

are expressed on immune cells to mark them for separation
function as receptors for cytokine and CAMs
allow leukocytes to recognize antigen
are each expressed on only one cell type

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immunity blocks the activation of adaptive immune effector cells
antigen is hidden from the immune system in macrophages
innate immune effectors are eliminating antigen

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