Antigen
Very low doses of antigen may induce

low zone tolerance
hypersensitivity
low zone immunity
immunological ignorance

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Antigen
During the lag period between antigen contact and detection of adaptive immunity,

innate immunity blocks the activation of adaptive immune effector cells
antigen is hidden from the immune system in macrophages
innate immune effectors are eliminating antigen
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow

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