Antigen
During the lag period between antigen contact and detection of adaptive immunity,

antigen is hidden from the immune system in macrophages
innate immunity blocks the activation of adaptive immune effector cells
new B and T cells with the appropriate antigen specificity must be produced in the bone marrow
innate immune effectors are eliminating antigen

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Antigen
For specific antigen recognition by T cells,

denaturation of antigen does not reduce epitope recognition
antigen is bound by a T cell membrane antibody
MHC molecules are not required
antigen exposure during T cell maturation is required

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