Microorganisms and Disease
What is common in catheters and ventilators?

They are used primarily in neonatal intensive care units
They predispose patients to viral rather than bacterial infections
They bypass important defenses of the body
Bacteria responsible for associated infections are usually susceptible to antibiotics

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Microorganisms and Disease
The "A" subunit of diphtheria toxin

lysis macrophages with the release of cytokines
forms cAMP that leads to fluid accumulation
binds host cell receptors found on heart cells
cause ADP ribosylation of a factor involved in protein synthesis

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Microorganisms and Disease
Prontosil is

an effective antibacterial both in animals as well as in in-vitro cultures
an effective antibacterial when used in in-vitro cultures
an effective antibacterial when used in animals
not used as an antibacterial agent

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Microorganisms and Disease
Cholera toxin is an A-B type toxin in which the B portions bind to a receptor on a host cell and the A portion enters the cell to cause

ADP ribosylation of adenylate cyclase that stops production of cAMP
cleavage of rRNA that results in disruption of ribosome function
ADP ribosylation of guanylate cyclase that stimulates production of cGMP
ADP ribosylation of a G protein that locks it into an active form that stimulates adenylate cyclase to make cAMP

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