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Structure and Properties of Peptides

Structure and Properties of Peptides
When pO2 = Kd of myoglobin, the fractional saturation (YO2) is about

0.9
0.1
0.5
1.7

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Structure and Properties of Peptides
Peptides in the fully extended chain conformation

also have a cis geometry in their peptide bonds
have Y = F = 180°
are equivalent to the (3-sheet structure
do not occur in nature

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Structure and Properties of Peptides
In β-pleated sheet structures neighbouring

neighboring chains are connected by a-helices
neighboring chains are hydrogen bonded
chains lie in a flat plane
neighboring residues are hydrogen bonded

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Structure and Properties of Peptides
The resonance structures that can be drawn for the peptide bond indicate that the peptide bond

is still not completely understood
has partial double bond character
both (a) and (b)
is stronger than an ordinary single bond

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Structure and Properties of Peptides
Hydrogen bonds in a-helices are

not present at Phe residues
roughly parallel to the helix axis
more numerous than Vander Waals interactions
analogous to the steps in a spiral staircase

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Structure and Properties of Peptides
The different orders of protein structure are determined by all of the following bond types except

disulfide bridges
peptide bonds
hydrogen bonds
phospho-diester bonds

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