DNA Sequencing, Mutation and Repair
A nonsense mutation may result into

modification of mRNA
a premature termination of the synthesis of a polypeptide
a large deletion within the reading frame of a gene
an abnormal elongation of a polypeptide

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DNA Sequencing, Mutation and Repair
The whole-genome shotgun sequencing approach depends primarily on

sequencing the bacterial chromosome while it is still intact
All of these
methodical sequencing a few large cloned fragments of DNA
rapidly sequencing thousands of small randomly cloned fragments

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