DNA Sequencing, Mutation and Repair
A nonsense mutation may result into

a premature termination of the synthesis of a polypeptide
a large deletion within the reading frame of a gene
modification of mRNA
an abnormal elongation of a polypeptide

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DNA Sequencing, Mutation and Repair
The whole-genome shotgun sequencing approach depends primarily on

methodical sequencing a few large cloned fragments of DNA
rapidly sequencing thousands of small randomly cloned fragments
sequencing the bacterial chromosome while it is still intact
All of these

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