DNA Sequencing, Mutation and Repair
A nonsense mutation introduced into the DNA sequence of a gene may

cause a shift in reading frame
have no effect on the transcript or protein made
cause premature termination of the mRNA
shorten the length of the protein encoded by the gene

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DNA Sequencing, Mutation and Repair
The whole-genome shotgun sequencing approach depends primarily on

All of these
sequencing the bacterial chromosome while it is still intact
rapidly sequencing thousands of small randomly cloned fragments
methodical sequencing a few large cloned fragments of DNA

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DNA Sequencing, Mutation and Repair
A mutagen is defined as

a molecule which stabilizes DNA thus prevents mutations from occurring
an enzyme that repairs mutations
a chemical or physical agent that induces mutations
an inhibitor of gene modification

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