Antibody
Which is not a function of IgG?

First antibody type produced against an antigen during the primary antibody response
Involved in opsonization
Major antibody in serum
Activates or fixes complement

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Antibody
Self reactive antibodies are not found in significant concentration in normal serum because

B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
it is impossible to generate a self-reactive antibody
self reactive B cells are killed by CD8 T cells
self reactive B cells switch to IgA which is all secreted and not present in serum

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