Carbohydrate
The multistep pathways of metabolism are efficient because they

spread the enzymes for a pathway into several different organelles
use the same enzyme for all of the substrates in the pathway
use the same substrate for all of the enzymes in the pathway
locate all of the enzymes for a pathway in the same place within the cell

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Carbohydrate
When living organisms are cooled below some critical body temperature, the metabolic reactions within their cells cease to function properly. This malfunction occurs because

there is insufficient molecular motion for substrates to interact
the activation energy for the reaction is raised
their enzymes lose the proper three-dimensional shape
enzyme active sites become permanently bound to substrates

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