DNA Structure and Replication
In DNA, nucleotides are covalently joined together by

2', 3' phosphodiester bonds to form a repetitive sugar-phosphate chain
2', 5' phosphodiester bonds to form a repetitive sugar-phosphate chain
3', 4' phosphodiester bonds to form a repetitive sugar-phosphate chain
3', 5' phosphodiester bonds to form a repetitive sugar-phosphate chain

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DNA Structure and Replication
The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

It lacks a proofreading exonuclease
The RNase H domain of p66 causes error prone synthesis
AZT (zidovudine) is too expensive to be taken in effective doses
It has low affinity for the correct dNTP's

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