ORDERING OF SENTENCES QUIZ

An autoimmune disease is

AIDS

Lupus

Mumps

Measles

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Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

limited life span of more mature hematopoietic cells

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Bone marrow given to an infant with SCID must

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

be irradiated to eliminate GVHD

come from a donor that shares some MHC alleles with the recipient

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 0-3 months of age

in utero (before birth)

at 3-12 months of age

at 12-24 months of age

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr

Leu or Ileu

Tyr or Phe

His or Pro

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The HIV virus infects primarily

brain cells

liver cells

red blood cells

cells in the immune system

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

transporter of antigen peptides (TAP)

class II MHC

HIV infection of CD4+ T cells

a thymus

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

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Specific translocations are associated with

pancreatic cancer

breast cancer

some leukemias

colon cancer

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