MONOCLONAL ANTIBODIES QUIZ

The EBV-hybridoma technique

All of these

gives much higher hybridization frequencies

immortalizes the donor Bcells

facilitates the proliferation of antigen specific B cells

TRUE ANSWER : ?
YOUR ANSWER : ?

The cross linkage of antigens by antibodies is known as

agglutination

complement fixation

all of these

a cross reaction

TRUE ANSWER : ?
YOUR ANSWER : ?

The primary B cell receptor is

IgA

IgD

IgG

IgE

TRUE ANSWER : ?
YOUR ANSWER : ?

Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

absence of human immune response against murine proteins (HAMA) response

presence of HAMA response

All of these

poor recognition of immunoglobulin, Ig constant regions

TRUE ANSWER : ?
YOUR ANSWER : ?

Which type of cell actually secrets antibodies?

dendritic cells

T cells

macrophages

plasma cells

TRUE ANSWER : ?
YOUR ANSWER : ?

Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with

IgG

Ig MAbs

IgE

IgA

TRUE ANSWER : ?
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The antigen-specific lymphocytes can be immortalized by which of the following method?

Hybridization with a suitable lymphoid tumor cell

All of these

Transformation following infection by Epstein-Barr virus (EB V)

Transfection with tumor derived DNA

TRUE ANSWER : ?
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Small simple molecules are

heterophilic antigens

rich antigens

moderate antigens

poor antigens

TRUE ANSWER : ?
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TC cells are important in controlling

allergy

virus infections

autoimmunity

all of these

TRUE ANSWER : ?
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The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

transformation of antigen specific B lymphocytes (EBV)

all of these

hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes

combination of EB Vand hybridoma techniques

TRUE ANSWER : ?
YOUR ANSWER : ?