MONOCLONAL ANTIBODIES QUIZ

In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a

hybridoma

natural killer cell

lymphoblast

myeloma

TRUE ANSWER : ?
YOUR ANSWER : ?

TC cells are important in controlling

all of these

allergy

autoimmunity

virus infections

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The EBV-hybridoma technique

immortalizes the donor Bcells

All of these

facilitates the proliferation of antigen specific B cells

gives much higher hybridization frequencies

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The cross linkage of antigens by antibodies is known as

complement fixation

a cross reaction

agglutination

all of these

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The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

all of these

combination of EB Vand hybridoma techniques

transformation of antigen specific B lymphocytes (EBV)

hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes

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The Ig locus is about

l/3rd of all hybridomas

l/2nd of all hybridomas

1/4th of all hybridomas

2/3rd of all hybridomas

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The primary B cell receptor is

IgA

IgE

IgG

IgD

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Small simple molecules are

moderate antigens

heterophilic antigens

poor antigens

rich antigens

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In human B cells and T cells are matured in the

none of these

lymph nodes and spleen respectively

bursa and thymus respectively

bone marrow and thymus respectively

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Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

poor recognition of immunoglobulin, Ig constant regions

All of these

absence of human immune response against murine proteins (HAMA) response

presence of HAMA response

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