MONOCLONAL ANTIBODIES QUIZ

Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the

poor recognition of immunoglobulin, Ig constant regions

absence of human immune response against murine proteins (HAMA) response

presence of HAMA response

All of these

TRUE ANSWER : ?
YOUR ANSWER : ?

Small simple molecules are

moderate antigens

rich antigens

heterophilic antigens

poor antigens

TRUE ANSWER : ?
YOUR ANSWER : ?

The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as

all of these

transformation of antigen specific B lymphocytes (EBV)

combination of EB Vand hybridoma techniques

hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes

TRUE ANSWER : ?
YOUR ANSWER : ?

In human B cells and T cells are matured in the

lymph nodes and spleen respectively

bone marrow and thymus respectively

none of these

bursa and thymus respectively

TRUE ANSWER : ?
YOUR ANSWER : ?

Helper T cells assist in the functions of

certain T cells

None of these

certain B cells and other T cells

certain B cells

TRUE ANSWER : ?
YOUR ANSWER : ?

The Ig locus is about

1/4th of all hybridomas

l/2nd of all hybridomas

l/3rd of all hybridomas

2/3rd of all hybridomas

TRUE ANSWER : ?
YOUR ANSWER : ?

The antigen-specific lymphocytes can be immortalized by which of the following method?

Hybridization with a suitable lymphoid tumor cell

Transformation following infection by Epstein-Barr virus (EB V)

All of these

Transfection with tumor derived DNA

TRUE ANSWER : ?
YOUR ANSWER : ?

In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,

T8 cells are greatly increased

T8 cells are greatly reduced

T4 cells are greatly reduced

T4 cells are greatly increased

TRUE ANSWER : ?
YOUR ANSWER : ?

Which type of cell actually secrets antibodies?

T cells

plasma cells

dendritic cells

macrophages

TRUE ANSWER : ?
YOUR ANSWER : ?

The cross linkage of antigens by antibodies is known as

complement fixation

agglutination

all of these

a cross reaction

TRUE ANSWER : ?
YOUR ANSWER : ?