DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

The primary reason for AIDS, a deadly disease is that it

causes a breakdown of the body's inflammatory response

is caused by a bacterium

is caused by a virus

destroys key components of the body's internal defense system

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Bone marrow given to an infant with SCID must

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

recombinant mouse for CD3

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

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Which of the Rous sarcoma virus has a homologous cellular protein?

c-src

v-src

v-ha-ras

v-ha-src

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Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

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An example of an immunodeficiency disorder is

AIDS

thyroiditis

rheumatic fever

systemic lupus erythematosus

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

in utero (before birth)

at 12-24 months of age

at 3-12 months of age

at 0-3 months of age

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An autoimmune disease is

Measles

AIDS

Lupus

Mumps

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

activation of B cells by T-independent antigens

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs are rapidly degraded

the drugs that are good inhibitors cannot by synthesized

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