DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

His or Pro

Leu or Ileu

Ser or Thr

Tyr or Phe

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

CD8 T cell-mediated cytotoxicity

IgG synthesis

macrophage activation to vesicular pathogens

alternative complement activation.

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

recombinant mouse for CD3

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

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Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

inserting a gene so that it will function properly

limited life span of more mature hematopoietic cells

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An autoimmune disease is

Measles

Lupus

Mumps

AIDS

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Specific translocations are associated with

breast cancer

colon cancer

pancreatic cancer

some leukemias

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus

HIV infection of CD4+ T cells

transporter of antigen peptides (TAP)

class II MHC

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

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