DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Combined cellular and humoral immune deficiencies result from lack of all of the following except

transporter of antigen peptides (TAP)

class II MHC

HIV infection of CD4+ T cells

a thymus

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

IgG synthesis

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

in utero (before birth)

at 12-24 months of age

at 3-12 months of age

at 0-3 months of age

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Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

GVHD caused by mature T cells in the transplanted cells

inserting a gene so that it will function properly

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Which of the Rous sarcoma virus has a homologous cellular protein?

c-src

v-ha-src

v-src

v-ha-ras

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The HIV virus infects primarily

brain cells

red blood cells

cells in the immune system

liver cells

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr

Leu or Ileu

His or Pro

Tyr or Phe

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

nude mouse

recombinant mouse for CD3

knock-out mouse for a thymus

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To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs that are good inhibitors cannot by synthesized

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