DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

recombinant mouse for CD3

knock-out mouse for a thymus

nude mouse

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Which of the Rous sarcoma virus has a homologous cellular protein?

c-src

v-src

v-ha-ras

v-ha-src

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An autoimmune disease is

Mumps

Measles

Lupus

AIDS

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens

CD8 T cell-mediated cytotoxicity

alternative complement activation.

IgG synthesis

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To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded

the drugs interfere with normal digestion

the drugs that are good inhibitors cannot by synthesized

the virus particles with altered (mutant) proteases arise

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Retinoblastoma is due to a mutation in a

viral gene

kinase

cyclin

tumor supressor

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

class II MHC

a thymus

transporter of antigen peptides (TAP)

HIV infection of CD4+ T cells

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A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages

bacterial infections

mucosal pathogens

infections following dental work due to bacteria entering the bloodstream

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Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

limited life span of more mature hematopoietic cells

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

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