DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

An autoimmune disease is

AIDS

Lupus

Measles

Mumps

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC

CTL killing of viruses

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-ras

v-src

c-src

v-ha-src

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Bone marrow given to an infant with SCID must

come from one of the child's parents

be irradiated to eliminate GVHD

come from a donor that shares some MHC alleles with the recipient

contain mature T cells that can begin making immune responses immediately

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Retinoblastoma is due to a mutation in a

viral gene

tumor supressor

cyclin

kinase

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

activation of B cells by T-independent antigens

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The chemical, typically released by the body in an allergic response is

histamine

allergens

perforins

antihistamines

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The primary reason for AIDS, a deadly disease is that it

causes a breakdown of the body's inflammatory response

destroys key components of the body's internal defense system

is caused by a virus

is caused by a bacterium

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

knock-out mouse for RAG-1 and RAG-2

recombinant mouse for CD3

knock-out mouse for a thymus

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A selective IgA deficiency would be expected to result in problems with

mucosal pathogens

bacterial infections

pathogens which can survive inside macrophages

infections following dental work due to bacteria entering the bloodstream

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