DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Tyr or Phe

Leu or Ileu

Ser or Thr

His or Pro

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Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

GVHD caused by mature T cells in the transplanted cells

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-ras

v-src

c-src

v-ha-src

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Specific translocations are associated with

colon cancer

some leukemias

breast cancer

pancreatic cancer

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus

class II MHC

transporter of antigen peptides (TAP)

HIV infection of CD4+ T cells

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The HIV virus infects primarily

cells in the immune system

liver cells

brain cells

red blood cells

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens

alternative complement activation.

IgG synthesis

CD8 T cell-mediated cytotoxicity

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

CTL killing of viruses

dendritic cell activation to become a mature APC

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A selective IgA deficiency would be expected to result in problems with

bacterial infections

infections following dental work due to bacteria entering the bloodstream

mucosal pathogens

pathogens which can survive inside macrophages

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