DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Tyr or Phe

Leu or Ileu

Ser or Thr

His or Pro

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The HIV virus infects primarily

brain cells

cells in the immune system

red blood cells

liver cells

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of B cells to provide co-stimulation for Th2 activation

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An example of an immunodeficiency disorder is

AIDS

systemic lupus erythematosus

rheumatic fever

thyroiditis

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

nude mouse

recombinant mouse for CD3

knock-out mouse for a thymus

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

alternative complement activation.

IgG synthesis

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 3-12 months of age

at 12-24 months of age

at 0-3 months of age

in utero (before birth)

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Which of the Rous sarcoma virus has a homologous cellular protein?

c-src

v-ha-src

v-src

v-ha-ras

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The chemical, typically released by the body in an allergic response is

perforins

antihistamines

allergens

histamine

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs that are good inhibitors cannot by synthesized

the drugs are rapidly degraded

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