DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells

inserting a gene so that it will function properly

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Tyr or Phe

Ser or Thr

His or Pro

Leu or Ileu

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus

class II MHC

transporter of antigen peptides (TAP)

HIV infection of CD4+ T cells

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

macrophage activation to vesicular pathogens

CD8 T cell-mediated cytotoxicity

IgG synthesis

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Retinoblastoma is due to a mutation in a

tumor supressor

kinase

cyclin

viral gene

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

recombinant mouse for CD3

knock-out mouse for RAG-1 and RAG-2

knock-out mouse for a thymus

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The HIV virus infects primarily

red blood cells

liver cells

cells in the immune system

brain cells

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A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages

bacterial infections

mucosal pathogens

infections following dental work due to bacteria entering the bloodstream

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age

at 3-12 months of age

at 0-3 months of age

in utero (before birth)

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The chemical, typically released by the body in an allergic response is

histamine

perforins

antihistamines

allergens

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