DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

A selective IgA deficiency would be expected to result in problems with

infections following dental work due to bacteria entering the bloodstream

pathogens which can survive inside macrophages

bacterial infections

mucosal pathogens

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Retinoblastoma is due to a mutation in a

kinase

tumor supressor

viral gene

cyclin

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An example of an immunodeficiency disorder is

systemic lupus erythematosus

rheumatic fever

AIDS

thyroiditis

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

infected cell processing of virus peptides

dendritic cell activation to become a mature APC

macrophage intracellular killing of bacteria

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

class II MHC

a thymus

HIV infection of CD4+ T cells

transporter of antigen peptides (TAP)

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Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

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To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized

the drugs interfere with normal digestion

the virus particles with altered (mutant) proteases arise

the drugs are rapidly degraded

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

macrophage activation to vesicular pathogens

IgG synthesis

CD8 T cell-mediated cytotoxicity

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-src

c-src

v-ha-ras

v-ha-src

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Specific translocations are associated with

pancreatic cancer

breast cancer

some leukemias

colon cancer

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