DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell proliferation

activation of B cells by T-independent antigens

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria

infected cell processing of virus peptides

dendritic cell activation to become a mature APC

CTL killing of viruses

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-src

c-src

v-src

v-ha-ras

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A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages

mucosal pathogens

bacterial infections

infections following dental work due to bacteria entering the bloodstream

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Specific translocations are associated with

some leukemias

colon cancer

pancreatic cancer

breast cancer

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The HIV virus infects primarily

cells in the immune system

liver cells

brain cells

red blood cells

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An example of an immunodeficiency disorder is

rheumatic fever

systemic lupus erythematosus

thyroiditis

AIDS

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

knock-out mouse for a thymus

nude mouse

recombinant mouse for CD3

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An autoimmune disease is

AIDS

Lupus

Mumps

Measles

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis

CD8 T cell-mediated cytotoxicity

alternative complement activation.

macrophage activation to vesicular pathogens

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