DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

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Specific translocations are associated with

breast cancer

pancreatic cancer

some leukemias

colon cancer

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The primary reason for AIDS, a deadly disease is that it

is caused by a bacterium

destroys key components of the body's internal defense system

is caused by a virus

causes a breakdown of the body's inflammatory response

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The chemical, typically released by the body in an allergic response is

allergens

histamine

antihistamines

perforins

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr

Tyr or Phe

His or Pro

Leu or Ileu

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

recombinant mouse for CD3

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

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Retinoblastoma is due to a mutation in a

tumor supressor

kinase

viral gene

cyclin

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Which of the Rous sarcoma virus has a homologous cellular protein?

c-src

v-ha-ras

v-ha-src

v-src

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An autoimmune disease is

Measles

Mumps

AIDS

Lupus

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

transporter of antigen peptides (TAP)

a thymus

HIV infection of CD4+ T cells

class II MHC

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