DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

recombinant mouse for CD3

nude mouse

knock-out mouse for RAG-1 and RAG-2

knock-out mouse for a thymus

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

HIV infection of CD4+ T cells

class II MHC

transporter of antigen peptides (TAP)

a thymus

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An autoimmune disease is

AIDS

Mumps

Lupus

Measles

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria

dendritic cell activation to become a mature APC

CTL killing of viruses

infected cell processing of virus peptides

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The HIV virus infects primarily

red blood cells

brain cells

cells in the immune system

liver cells

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Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

contain mature T cells that can begin making immune responses immediately

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Tyr or Phe

His or Pro

Leu or Ileu

Ser or Thr

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 3-12 months of age

at 12-24 months of age

at 0-3 months of age

in utero (before birth)

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Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells

GVHD caused by mature T cells in the transplanted cells

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

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Retinoblastoma is due to a mutation in a

tumor supressor

kinase

cyclin

viral gene

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