DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-ras

v-ha-src

c-src

v-src

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Specific translocations are associated with

colon cancer

some leukemias

breast cancer

pancreatic cancer

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To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded

the drugs that are good inhibitors cannot by synthesized

the drugs interfere with normal digestion

the virus particles with altered (mutant) proteases arise

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Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

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An example of an immunodeficiency disorder is

rheumatic fever

AIDS

systemic lupus erythematosus

thyroiditis

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Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC

CTL killing of viruses

macrophage intracellular killing of bacteria

infected cell processing of virus peptides

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A selective IgA deficiency would be expected to result in problems with

bacterial infections

pathogens which can survive inside macrophages

infections following dental work due to bacteria entering the bloodstream

mucosal pathogens

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The primary reason for AIDS, a deadly disease is that it

is caused by a virus

is caused by a bacterium

destroys key components of the body's internal defense system

causes a breakdown of the body's inflammatory response

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