DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus

transporter of antigen peptides (TAP)

class II MHC

HIV infection of CD4+ T cells

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

macrophage intracellular killing of bacteria

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

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To treat HIV infections using drugs, the major problem is that

the drugs are rapidly degraded

the drugs interfere with normal digestion

the drugs that are good inhibitors cannot by synthesized

the virus particles with altered (mutant) proteases arise

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of B cells to provide co-stimulation for Th2 activation

activation of B cells by T-independent antigens

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An autoimmune disease is

Lupus

Mumps

Measles

AIDS

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age

at 0-3 months of age

in utero (before birth)

at 3-12 months of age

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The HIV virus infects primarily

liver cells

red blood cells

brain cells

cells in the immune system

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Specific translocations are associated with

colon cancer

some leukemias

pancreatic cancer

breast cancer

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

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Retinoblastoma is due to a mutation in a

cyclin

tumor supressor

kinase

viral gene

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