DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

The chemical, typically released by the body in an allergic response is

allergens

antihistamines

histamine

perforins

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

transporter of antigen peptides (TAP)

a thymus

HIV infection of CD4+ T cells

class II MHC

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

IgG synthesis

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Retinoblastoma is due to a mutation in a

kinase

tumor supressor

cyclin

viral gene

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Bone marrow given to an infant with SCID must

contain mature T cells that can begin making immune responses immediately

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

come from one of the child's parents

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation

activation of B cells by T-independent antigens

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

CTL killing of viruses

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

His or Pro

Ser or Thr

Tyr or Phe

Leu or Ileu

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs that are good inhibitors cannot by synthesized

the drugs are rapidly degraded

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age

in utero (before birth)

at 0-3 months of age

at 3-12 months of age

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