DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages

mucosal pathogens

infections following dental work due to bacteria entering the bloodstream

bacterial infections

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Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

nude mouse

recombinant mouse for CD3

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

come from one of the child's parents

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age

in utero (before birth)

at 0-3 months of age

at 3-12 months of age

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Retinoblastoma is due to a mutation in a

tumor supressor

cyclin

kinase

viral gene

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

CD8 T cell-mediated cytotoxicity

IgG synthesis

macrophage activation to vesicular pathogens

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of B cells to provide co-stimulation for Th2 activation

activation of B cells by T-independent antigens

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

infected cell processing of virus peptides

CTL killing of viruses

dendritic cell activation to become a mature APC

macrophage intracellular killing of bacteria

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs that are good inhibitors cannot by synthesized

the drugs interfere with normal digestion

the drugs are rapidly degraded

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