DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

infected cell processing of virus peptides

dendritic cell activation to become a mature APC

macrophage intracellular killing of bacteria

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Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

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An example of an immunodeficiency disorder is

AIDS

systemic lupus erythematosus

thyroiditis

rheumatic fever

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To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized

the drugs are rapidly degraded

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus

nude mouse

knock-out mouse for RAG-1 and RAG-2

recombinant mouse for CD3

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Tyr or Phe

Leu or Ileu

His or Pro

Ser or Thr

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An autoimmune disease is

Measles

Mumps

Lupus

AIDS

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

contain mature T cells that can begin making immune responses immediately

come from one of the child's parents

be irradiated to eliminate GVHD

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens

IgG synthesis

CD8 T cell-mediated cytotoxicity

alternative complement activation.

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 0-3 months of age

at 3-12 months of age

at 12-24 months of age

in utero (before birth)

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