DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

IgG synthesis

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 12-24 months of age

at 3-12 months of age

in utero (before birth)

at 0-3 months of age

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-src

c-src

v-ha-ras

v-ha-src

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria

infected cell processing of virus peptides

CTL killing of viruses

dendritic cell activation to become a mature APC

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The HIV virus infects primarily

brain cells

red blood cells

liver cells

cells in the immune system

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Retinoblastoma is due to a mutation in a

kinase

tumor supressor

cyclin

viral gene

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

knock-out mouse for a thymus

nude mouse

recombinant mouse for CD3

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Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

transducing genetic material into stem cells

GVHD caused by mature T cells in the transplanted cells

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

His or Pro

Leu or Ileu

Tyr or Phe

Ser or Thr

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Bone marrow given to an infant with SCID must

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

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