DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis

alternative complement activation.

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

macrophage intracellular killing of bacteria

dendritic cell activation to become a mature APC

CTL killing of viruses

infected cell processing of virus peptides

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Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells

limited life span of more mature hematopoietic cells

transducing genetic material into stem cells

inserting a gene so that it will function properly

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Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

come from a donor that shares some MHC alleles with the recipient

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

His or Pro

Leu or Ileu

Tyr or Phe

Ser or Thr

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

recombinant mouse for CD3

knock-out mouse for RAG-1 and RAG-2

knock-out mouse for a thymus

nude mouse

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An example of an immunodeficiency disorder is

thyroiditis

systemic lupus erythematosus

AIDS

rheumatic fever

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Specific translocations are associated with

breast cancer

colon cancer

some leukemias

pancreatic cancer

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A selective IgA deficiency would be expected to result in problems with

mucosal pathogens

infections following dental work due to bacteria entering the bloodstream

pathogens which can survive inside macrophages

bacterial infections

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An autoimmune disease is

Mumps

Measles

AIDS

Lupus

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