DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Bone marrow given to an infant with SCID must

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

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Difficulties with somatic gene therapy arise from all of the following except

transducing genetic material into stem cells

limited life span of more mature hematopoietic cells

inserting a gene so that it will function properly

GVHD caused by mature T cells in the transplanted cells

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Retinoblastoma is due to a mutation in a

cyclin

tumor supressor

viral gene

kinase

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The HIV virus infects primarily

red blood cells

cells in the immune system

liver cells

brain cells

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

a thymus

HIV infection of CD4+ T cells

class II MHC

transporter of antigen peptides (TAP)

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for RAG-1 and RAG-2

nude mouse

knock-out mouse for a thymus

recombinant mouse for CD3

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Specific translocations are associated with

colon cancer

breast cancer

some leukemias

pancreatic cancer

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Ser or Thr

Leu or Ileu

His or Pro

Tyr or Phe

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

activation of B cells by T-independent antigens

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The primary reason for AIDS, a deadly disease is that it

causes a breakdown of the body's inflammatory response

is caused by a virus

is caused by a bacterium

destroys key components of the body's internal defense system

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