DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-src

v-src

v-ha-ras

c-src

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YOUR ANSWER : ?

DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

nude mouse

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

recombinant mouse for CD3

TRUE ANSWER : ?
YOUR ANSWER : ?

Infants are most susceptible to bacterial infection due to low circulating levels of IgG

in utero (before birth)

at 0-3 months of age

at 12-24 months of age

at 3-12 months of age

TRUE ANSWER : ?
YOUR ANSWER : ?

X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

activation of B cells by T-independent antigens

failure of B cells to provide co-stimulation for Th2 activation

failure of Th2 cells to provide co-stimulation for B cell isotype switching

failure of Th2 cells to provide co-stimulation for B cell proliferation

TRUE ANSWER : ?
YOUR ANSWER : ?

Retinoblastoma is due to a mutation in a

tumor supressor

cyclin

viral gene

kinase

TRUE ANSWER : ?
YOUR ANSWER : ?

If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

IgG synthesis

macrophage activation to vesicular pathogens

CD8 T cell-mediated cytotoxicity

alternative complement activation.

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YOUR ANSWER : ?

The chemical, typically released by the body in an allergic response is

antihistamines

perforins

allergens

histamine

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YOUR ANSWER : ?

To treat HIV infections using drugs, the major problem is that

the drugs that are good inhibitors cannot by synthesized

the drugs are rapidly degraded

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

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YOUR ANSWER : ?

Difficulties with somatic gene therapy arise from all of the following except

limited life span of more mature hematopoietic cells

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

inserting a gene so that it will function properly

TRUE ANSWER : ?
YOUR ANSWER : ?

Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

macrophage intracellular killing of bacteria

CTL killing of viruses

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YOUR ANSWER : ?