DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs are rapidly degraded

the drugs that are good inhibitors cannot by synthesized

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The chemical, typically released by the body in an allergic response is

allergens

antihistamines

perforins

histamine

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A selective IgA deficiency would be expected to result in problems with

mucosal pathogens

pathogens which can survive inside macrophages

infections following dental work due to bacteria entering the bloodstream

bacterial infections

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-src

v-src

v-ha-ras

c-src

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of B cells to provide co-stimulation for Th2 activation

activation of B cells by T-independent antigens

failure of Th2 cells to provide co-stimulation for B cell isotype switching

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Retinoblastoma is due to a mutation in a

tumor supressor

kinase

cyclin

viral gene

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus

nude mouse

recombinant mouse for CD3

knock-out mouse for RAG-1 and RAG-2

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The HIV virus infects primarily

brain cells

cells in the immune system

liver cells

red blood cells

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Difficulties with somatic gene therapy arise from all of the following except

GVHD caused by mature T cells in the transplanted cells

transducing genetic material into stem cells

inserting a gene so that it will function properly

limited life span of more mature hematopoietic cells

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

IgG synthesis

macrophage activation to vesicular pathogens

CD8 T cell-mediated cytotoxicity

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