DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

transducing genetic material into stem cells

GVHD caused by mature T cells in the transplanted cells

limited life span of more mature hematopoietic cells

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Specific translocations are associated with

some leukemias

breast cancer

colon cancer

pancreatic cancer

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

Leu or Ileu

Tyr or Phe

Ser or Thr

His or Pro

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Bone marrow given to an infant with SCID must

come from one of the child's parents

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens

CD8 T cell-mediated cytotoxicity

alternative complement activation.

IgG synthesis

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The primary reason for AIDS, a deadly disease is that it

causes a breakdown of the body's inflammatory response

destroys key components of the body's internal defense system

is caused by a bacterium

is caused by a virus

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Chronic granulomatous disease results from a failure to perform oxidative burst. This deficiency would be most likely to interfere with

CTL killing of viruses

macrophage intracellular killing of bacteria

dendritic cell activation to become a mature APC

infected cell processing of virus peptides

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus

nude mouse

knock-out mouse for RAG-1 and RAG-2

recombinant mouse for CD3

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs that are good inhibitors cannot by synthesized

the drugs are rapidly degraded

the drugs interfere with normal digestion

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The HIV virus infects primarily

liver cells

cells in the immune system

red blood cells

brain cells

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