DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Specific translocations are associated with

some leukemias

pancreatic cancer

breast cancer

colon cancer

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Difficulties with somatic gene therapy arise from all of the following except

inserting a gene so that it will function properly

limited life span of more mature hematopoietic cells

transducing genetic material into stem cells

GVHD caused by mature T cells in the transplanted cells

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

be irradiated to eliminate GVHD

come from one of the child's parents

contain mature T cells that can begin making immune responses immediately

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

recombinant mouse for CD3

nude mouse

knock-out mouse for a thymus

knock-out mouse for RAG-1 and RAG-2

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-ras

c-src

v-src

v-ha-src

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An example of an immunodeficiency disorder is

thyroiditis

systemic lupus erythematosus

rheumatic fever

AIDS

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

macrophage activation to vesicular pathogens

IgG synthesis

CD8 T cell-mediated cytotoxicity

alternative complement activation.

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Combined cellular and humoral immune deficiencies result from lack of all of the following except

HIV infection of CD4+ T cells

transporter of antigen peptides (TAP)

a thymus

class II MHC

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To treat HIV infections using drugs, the major problem is that

the virus particles with altered (mutant) proteases arise

the drugs interfere with normal digestion

the drugs are rapidly degraded

the drugs that are good inhibitors cannot by synthesized

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Infants are most susceptible to bacterial infection due to low circulating levels of IgG

at 0-3 months of age

in utero (before birth)

at 3-12 months of age

at 12-24 months of age

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