DISEASE ASSOCIATED WITH IMMUNE SYSTEM QUIZ

Retinoblastoma is due to a mutation in a

tumor supressor

kinase

cyclin

viral gene

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Which of the Rous sarcoma virus has a homologous cellular protein?

v-ha-src

v-src

v-ha-ras

c-src

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An autoimmune disease is

Mumps

Lupus

AIDS

Measles

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Bone marrow given to an infant with SCID must

come from a donor that shares some MHC alleles with the recipient

come from one of the child's parents

be irradiated to eliminate GVHD

contain mature T cells that can begin making immune responses immediately

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An example of an immunodeficiency disorder is

AIDS

rheumatic fever

systemic lupus erythematosus

thyroiditis

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A selective IgA deficiency would be expected to result in problems with

pathogens which can survive inside macrophages

bacterial infections

infections following dental work due to bacteria entering the bloodstream

mucosal pathogens

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If Class IIMHC is not expressed in the thymus, the resulting immune deficiencies would include all of the following except reduced

alternative complement activation.

IgG synthesis

CD8 T cell-mediated cytotoxicity

macrophage activation to vesicular pathogens

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A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

His or Pro

Tyr or Phe

Leu or Ileu

Ser or Thr

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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be

failure of Th2 cells to provide co-stimulation for B cell proliferation

failure of B cells to provide co-stimulation for Th2 activation

activation of B cells by T-independent antigens

failure of Th2 cells to provide co-stimulation for B cell isotype switching

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DiGeorge's syndrome is characterized by the lack of a thymus The mouse model closest to this human disease would be a

knock-out mouse for a thymus

recombinant mouse for CD3

knock-out mouse for RAG-1 and RAG-2

nude mouse

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