ALLOSTERIC EFFECTS QUIZ

show a Hill coefficient (nH) of 0.0

show a Hill coefficient (nH) of n

only be found in either the unliganded form or the fully liganded form

both (b) and (c)

1.2 and 4.5

4.5 and 1.2

1.0 and 2.8

2.8 and 1.0

the absence of competing ligands

the presence of hydrating water molecules

the opposite chirality of the binding ligand

the amino acid residues lining the binding site

100-fold higher affinity for the last O2 bound than for the first

100-fold lower affinity for the last O2 bound than for the first

extensive protein conformational change

both (a) and (b)

its binding pocket becomes too small to accommodate BPG

it is displaced from the heme by movement of the proximal histidine

it is displaced from the heme by oxygen

BPG binds to the R state with the same affinity as the T state

increasing [H+]

decreasing Hb affinity for O2

increasing [H+] and decreasing Hb affinity for O2

increasing Hb affinity for O2

to maximize oxygen delivery to the tissues

for maintaining Fe in the Fe2+ state

to minimize oxygen delivery to the tissues

only in humans

both (a) and (c)

stabilizes the R state of the protein

increases the binding affinity

decreases the binding affinity

not defined

None of these

2

1

a linear Scatchard Plot

both (b) and (c)

a sigmodial binding curve

a hyperbolic binding curve