ALLOSTERIC EFFECTS QUIZ

show a Hill coefficient (nH) of n

both (b) and (c)

only be found in either the unliganded form or the fully liganded form

show a Hill coefficient (nH) of 0.0

for maintaining Fe in the Fe2+ state

to maximize oxygen delivery to the tissues

only in humans

to minimize oxygen delivery to the tissues

it is displaced from the heme by oxygen

it is displaced from the heme by movement of the proximal histidine

its binding pocket becomes too small to accommodate BPG

BPG binds to the R state with the same affinity as the T state

1.2 and 4.5

1.0 and 2.8

4.5 and 1.2

2.8 and 1.0

the presence of hydrating water molecules

the absence of competing ligands

the amino acid residues lining the binding site

the opposite chirality of the binding ligand

increases the binding affinity

decreases the binding affinity

both (a) and (c)

stabilizes the R state of the protein

binding of oxygen to the heme

reorganization of protein-protein contacts between the individual subunits

movement of the proximal histidine towards the heme

movement of the F-helix, which contains the proximal His

1

2

not defined

None of these

increasing [H+] and decreasing Hb affinity for O2

increasing Hb affinity for O2

decreasing Hb affinity for O2

increasing [H+]

a linear Scatchard Plot

a hyperbolic binding curve

both (b) and (c)

a sigmodial binding curve