18TH CENTURY REVOLTS AND REFORM QUIZ

the presence of hydrating water molecules

the absence of competing ligands

the amino acid residues lining the binding site

the opposite chirality of the binding ligand

4.5 and 1.2

2.8 and 1.0

1.0 and 2.8

1.2 and 4.5

a hyperbolic binding curve

a linear Scatchard Plot

both (b) and (c)

a sigmodial binding curve

show a Hill coefficient (nH) of 0.0

only be found in either the unliganded form or the fully liganded form

show a Hill coefficient (nH) of n

both (b) and (c)

not defined

1

2

None of these

movement of the proximal histidine towards the heme

movement of the F-helix, which contains the proximal His

binding of oxygen to the heme

reorganization of protein-protein contacts between the individual subunits

its binding pocket becomes too small to accommodate BPG

it is displaced from the heme by movement of the proximal histidine

it is displaced from the heme by oxygen

BPG binds to the R state with the same affinity as the T state

both (a) and (c)

decreases the binding affinity

stabilizes the R state of the protein

increases the binding affinity

100-fold lower affinity for the last O2 bound than for the first

both (a) and (b)

100-fold higher affinity for the last O2 bound than for the first

extensive protein conformational change

increasing [H+]

increasing [H+] and decreasing Hb affinity for O2

decreasing Hb affinity for O2

increasing Hb affinity for O2