Chemical Reaction Engineering
Enzymes are destroyed, when the

Reactant's concentration is very low
Temperature is very high
Reaction rate is independent of the reactant's concentration
Reactant's concentration is very high

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Chemical Reaction Engineering
The reactions of high molecularity are rare, because

Many body collisions are not favoured energetically
Of low probability of many body collisions
Of very large activation energy of many bodies
Of requirement of very large concentration for such reactions

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