Antibody
Antigen binding sites of an immunoglobulin are located in

light chain alone
Fc region of the antibody
heavy chain alone
Fab regions of the antibody

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Antibody
Self reactive antibodies are not found in significant concentration in normal serum because

it is impossible to generate a self-reactive antibody
B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
self reactive B cells switch to IgA which is all secreted and not present in serum
self reactive B cells are killed by CD8 T cells

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