Antibody
Antigen binding sites of an immunoglobulin are located in

Fab regions of the antibody
heavy chain alone
Fc region of the antibody
light chain alone

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Antibody
Self reactive antibodies are not found in significant concentration in normal serum because

self reactive B cells are killed by CD8 T cells
B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
self reactive B cells switch to IgA which is all secreted and not present in serum
it is impossible to generate a self-reactive antibody

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Antibody
The secretary component of sIgA is

made by T cells
made by plasma cells that secrete dimeric IgA
formed by cleavage of an epithelial cell receptor used to transport the dimeric IgA across the epithelial cell
added to dimeric IgA by the M cell

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