Antibody
Antigen binding sites of an immunoglobulin are located in

heavy chain alone
Fab regions of the antibody
Fc region of the antibody
light chain alone

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Antibody
Self reactive antibodies are not found in significant concentration in normal serum because

self reactive B cells are killed by CD8 T cells
B cells that are stimulated via their surface bound antibody in the absence of T cell help to commit suicide
it is impossible to generate a self-reactive antibody
self reactive B cells switch to IgA which is all secreted and not present in serum

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