Enzyme Reaction
An exergonic reaction is one that

looses energy
requires energy to proceed
releases energy for work
gives off much heat

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Enzyme Reaction
Hydrogen and oxygen release enormous amounts of energy when they react. Yet, hydrogen and oxygen can be mixed together in a balloon and nothing will happen. Why?

The energy of activation to form the transition-state complex is too high to allow the reaction to occur without assistance
Competitive inhibitors are blocking the reaction from occurring in the active site
There must be contaminating elements in the balloon that prohibit the reaction from occurring
All of these

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