Transgenic Plant
What are the various disadvantages of cross protection?

All of these
Possibility of unnecessary spread of mild virus
Possibility of mutations in inducing mild virus strain
Possibility of synergism between inducing virus and other unrelated virus

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Transgenic Plant
In transgenic plants that have been manipulated to express patho-genesis-related (PR) proteins all the time it has been shown that

expression of two PR proteins provides some protection against a few pathogens
these proteins trigger the production of other antimicrobial defenses
expression of one PR protein provides high levels of protection against many pathogens
these provide no protection at all against pathogens

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