Retroviridae
The problem(s) associated with development of a vaccine against HIV is/are

rapid mutation of HIV
all of these
antibody alone may be insufficient
virus can spread from cell to cell by fusion to produce syncytia

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Retroviridae
HIV or Human Immunodeficiency Virus is considered unique because each virus contains:

more than 100 copies of the viral genome
a viral enzyme known as reverse transcriptase
sticky proteins that allow it to bind tightly to host cells
a genome made up of both DNA and RNA components

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