DNA Replication
During DNA replication in prokaryotes, synthesis begins on the circular chromosome

always at the same place
at any stretch of DNA that is high in AT pairs
at the promoter
randomly on the chromosome

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DNA Replication
Proofreading activity to maintain the fidelity of DNA synthesis

is a function of the 3'-5' exonuclease activity of the DNA polymerases
occurs in prokaryotes but not eukaryotes
requires the presence of an enzyme separate from the DNA polymerases
occurs after the synthesis has been completed

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